Apache's mod_perl makes Perl applications run much faster and scale well to heavy usage. Using Kwiki with mod_perl is a piece of cake.
First you need is an Apache server built with mod_perl support. See http://perl.apache.org for more information.
Then install a Kwiki site following the normal Kwiki Installation procedures.
Finally add something like this to your Apache configuration:
That's it! You'll get an instant performance boost.
You can switch from the standard CGI installation to mod_perl anytime you want.